What is the difference between COX-1 and CO X-2?
In the 1990s, researchers discovered that two different COX enzymes existed, now known as COX-1 and COX-2. Cyclooxygenase-1 (COX-1) is known to be present in most tissues. In the gastrointestinal tract, COX-1 maintains the normal lining of the stomach. This enzyme is also involved in kidney and platelet function. Cyclooxygenase-2 (COX-2) is primarily present at sites of inflammation. While both COX-1 and COX-2 convert arachidonic acid to prostaglandin, resulting in pain and inflammation, the inhibition of COX-2 is considered desirable and not COX-1 because of its protective effects on the gastrointestinal tract.